Edward Lee Selected Research

omecamtiv mecarbil

1/2022	Pharmacokinetic Evaluation of the CYP3A4 and CYP2D6 Drug-Drug Interaction and CYP3A4 Induction Potential of Omecamtiv Mecarbil: Two Open-Label Studies in Healthy Subjects.
1/2022	Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Amiodarone and Digoxin in Healthy Subjects.
1/2022	Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects.
1/2022	Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
1/2022	Population Pharmacokinetic Properties of Omecamtiv Mecarbil in Healthy Subjects and Patients With Heart Failure With Reduced Ejection Fraction.
12/2021	Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
11/2021	Evaluation of drug-drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically-based pharmacokinetic model.
11/2021	Pharmacokinetics, Tolerability, and Safety of Single and Multiple Omecamtiv Mecarbil Doses in Healthy Japanese and Caucasian Subjects.
7/2021	Relative Bioavailability of Omecamtiv Mecarbil Pediatric Minitablet Formulations in Healthy Adult Subjects.
7/2021	Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator.

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Edward Lee Research Topics

Disease

17	Heart Failure 06/2022 - 01/2021
11	Neoplasms (Cancer) 01/2020 - 03/2005
6	Adenoma (Adenomas) 08/2020 - 01/2011
6	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 01/2012
5	Infections 04/2020 - 05/2005
5	Colonic Neoplasms (Colon Cancer) 11/2017 - 01/2010
3	Glaucoma 01/2022 - 04/2005
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2021 - 01/2018
3	Chronic Renal Insufficiency 04/2019 - 01/2018
2	Migraine Disorders (Migraine) 03/2022 - 01/2019
2	Pain (Aches) 01/2021 - 01/2020
2	Carcinogenesis 08/2020 - 01/2017
2	Fibrosis (Cirrhosis) 10/2019 - 01/2019
2	Body Weight (Weight, Body) 01/2019 - 01/2019
2	Crohn Disease (Crohn's Disease) 01/2019 - 01/2018
2	Secondary Hyperparathyroidism 01/2018 - 10/2012
2	Inflammation (Inflammations) 01/2017 - 04/2014
2	Mycoses (Diseases, Fungus) 12/2016 - 01/2016
2	Retinal Detachment (Retinal Detachments) 04/2016 - 11/2014
2	Neoplasm Metastasis (Metastasis) 01/2016 - 07/2015
2	Microsatellite Instability 01/2012 - 08/2008
2	Chromosomal Instability (Chromosome Stability) 01/2012 - 01/2010
2	Femoral Fractures (Femoral Fracture) 12/2011 - 05/2011
1	Hypesthesia (Numbness) 03/2022
1	Transient Global Amnesia 03/2022
1	Hypothyroidism 03/2022
1	Gastroesophageal Reflux (GERD) 03/2022
1	Amnesia (Dissociative Amnesia) 03/2022
1	Acute Coronary Syndrome 03/2022
1	Chest Pain (Chest Pains) 03/2022
1	Flatulence 01/2022
1	Dyspnea (Shortness of Breath) 10/2021
1	Lymphopenia (Lymphocytopenia) 10/2021
1	Ischemia 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 01/2021
1	Obesity 08/2020
1	Overweight 08/2020
1	Atrophy 01/2020
1	Whooping Cough (Pertussis) 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Diplopia (Double Vision) 01/2020

Drug/Important Bio-Agent (IBA)

13	omecamtiv mecarbilIBA 01/2022 - 01/2021
12	Cardiac MyosinsIBA 01/2022 - 01/2021
6	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2010
4	Monoclonal AntibodiesIBA 01/2019 - 03/2005
3	Apelin ReceptorsIBA 06/2022 - 03/2022
3	Cinacalcet (Sensipar)FDA Link 04/2019 - 10/2012
3	Denosumab FDA Link 02/2016 - 07/2012
2	Cytochrome P-450 CYP3AIBA 01/2022 - 04/2014
2	Calcibiotic Root Canal SealerIBA 08/2020 - 08/2008
2	VaccinesIBA 01/2020 - 10/2018
2	Retinaldehyde (Retinal)IBA 01/2020 - 04/2005
2	hydrogen sulfite (bisulfite)IBA 01/2020 - 01/2016
2	oxidized low density lipoproteinIBA 01/2019 - 11/2014
2	Pharmaceutical PreparationsIBA 01/2019 - 04/2014
2	Biomarkers (Surrogate Marker)IBA 11/2018 - 01/2016
2	Proteins (Proteins, Gene)FDA Link 11/2018 - 04/2014
2	Amino Acids FDA Link 01/2018 - 11/2017
2	16S Ribosomal RNAIBA 11/2017 - 01/2013
2	CytokinesIBA 01/2017 - 04/2014
2	Voriconazole (Vfend)FDA LinkGeneric 01/2017 - 01/2016
2	posaconazole FDA Link 12/2016 - 01/2016
2	Amphotericin B (Amphotericin)FDA LinkGeneric 12/2016 - 05/2005
2	EnzymesIBA 04/2014 - 01/2012
1	Sumatriptan (Imigran)FDA LinkGeneric 03/2022
1	Tryptamines (Triptans)IBA 03/2022
1	Dihydroergotamine (Agit)FDA LinkGeneric 03/2022
1	Latanoprost (Xalatan)FDA Link 01/2022
1	tafluprostIBA 01/2022
1	apraclonidine (Iopidine)FDA LinkGeneric 01/2022
1	Bimatoprost (Lumigan)FDA Link 01/2022
1	brinzolamide (Azopt)FDA Link 01/2022
1	Travoprost (Travatan)FDA Link 01/2022
1	Timolol (Blocadren)FDA LinkGeneric 01/2022
1	Brimonidine Tartrate (Alphagan)FDA LinkGeneric 01/2022
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2022
1	TabletsIBA 01/2022
1	dorzolamide (Trusopt)FDA LinkGeneric 01/2022
1	Rosuvastatin Calcium (Crestor)FDA Link 11/2021
1	Ferritins (Ferritin)IBA 10/2021
1	ProcalcitoninIBA 10/2021
1	Perilipin-2IBA 01/2021
1	Opioid Analgesics (Opioids)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	CateninsIBA 08/2020
1	Amyloid (Amyloid Fibrils)IBA 01/2020
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020
1	pertactin FDA Link 01/2020

Therapy/Procedure

5	Therapeutics 10/2018 - 07/2002
4	Length of Stay 01/2022 - 12/2016
3	Free Tissue Flaps 11/2007 - 11/2006
2	Injections 01/2020 - 01/2018
2	Renal Dialysis (Hemodialysis) 01/2019 - 01/2018
2	Vitrectomy 04/2016 - 11/2014
2	Radiotherapy 07/2015 - 11/2007
1	Drug Tapering 01/2022
1	Analgesia 01/2021
1	Catheters 01/2021
1	Contraindications 04/2020